TRANSLATIONAL PHYSIOLOGY Vagus nerve stimulation mitigates intrinsic cardiac neuronal and adverse myocyte remodeling postmyocardial infarction
نویسندگان
چکیده
Eric Beaumont, Elizabeth M. Southerland, Jean C. Hardwick, Gary L. Wright, Shannon Ryan, Ying Li, Bruce H. KenKnight, J. Andrew Armour, and Jeffrey L. Ardell Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee; Department of Biology, Ithaca College, Ithaca, New York; Cyberonics, Houston, Texas; and Department of Medicine, University of California Los Angeles Health System, Los Angeles, California
منابع مشابه
Vagus nerve stimulation mitigates intrinsic cardiac neuronal and adverse myocyte remodeling postmyocardial infarction.
This paper aims to determine whether chronic vagus nerve stimulation (VNS) mitigates myocardial infarction (MI)-induced remodeling of the intrinsic cardiac nervous system (ICNS), along with the cardiac tissue it regulates. Guinea pigs underwent VNS implantation on the right cervical vagus. Two weeks later, MI was produced by ligating the ventral descending coronary artery. VNS stimulation start...
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Our objective was to determine whether chronic vagus nerve stimulation (VNS) mitigates pressure overload (PO)-induced remodeling of the cardioneural interface. Guinea pigs (n = 48) were randomized to right or left cervical vagus (RCV or LCV) implant. After 2 wk, chronic left ventricular PO was induced by partial (15-20%) aortic constriction. Of the 31 animals surviving PO induction, 10 were ran...
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